MECHANISM OF PROTEINURIA

The Mechanism of Proteinuria

Mechanism of Proteinuria

Intraperitoneal administration of bovine albumin sharply increases glomerular permeability to hemoglobin in the rat kidney. In addition, bovine albumin "saturates" the tubular absorption mechanism and inhibits the tubular absorption of subsequently administered hemoglobin. Egg white, ovalbumin, and ovomucoid, in contrast, do not produce significant changes in glomerular permeability to hemoglob...

Studies on the Mechanism of Proteinuria.

In the chronic active stage of hemorrhagic Bright's disease there are often comparatively long intervals when the amount of functioning kidney tissue decreases very slowly and when there is no marked variation in glomerular permeability. With the patient on a standard regime the urea clearance remains constant, proteinuria fairly so, and blood samples taken under basal conditions with precautio...

Studies on the Mechanism of Experimental Proteinuria

When renin is administered intramuscularly to the rat, massive proteinuria occurs without a significant elevation of mean arterial blood pressure. The intravenous administration of renin to normal rats results in a great increase in urinary protein excretion. This response to renin is abolished by bilateral adrenalectomy. While the adrenalectomized rat fails to respond to intravenous renin with...

Studies on the Mechanism of Experimental Proteinuria Induced by Renin

Renin-induced proteinuria in the rat was investigated, with special emphasis on the relationship between the enzymatic activity and the proteinuric effect of renin. The dependence of the proteinuric effect on the enzymatic activity was shown by using (a) renin preparations of widely varying purity and (b) chemically modified "active" and "inactive" renin derivatives. Angiotensin II, the pressor...